San Francisco trimmed to 53 on roster cut day, with two quarterbacks kept for now and a suspension ahead for Demarcus Robinson. Drew Moss beat out Nick Zakel for a spot, while Sebastian Valdez and several veteran receivers were waved, signaling fortifying moves via waivers or the practice squad. Morstead’s return creates a temporary 54-man look and buys time to reallocate injuries and WR depth before Week 1. The offense remains led by Purdy and McCaffrey, with Kittle, Pearsall, Cowing and Moody shaping early fantasy angles.

Key fantasy implications center on SF’s crowded backfield at the start, uncertain WR depth, and the potential for waiver picks to fill the Week 1 roster. The roster shows a heavy tilt to offense and kicking coverage, with the defense aiming to stabilize through emerging young linemen and special-teams contributions.

Jauan Jennings's contract saga with the 49ers collides with a looming roster deadline and a calf injury clouding availability. The discussion pivots to incentives that could shape both sides’ leverage, and to how SF might navigate the WR depth if Jennings misses time. Replacement options like Ricky Pearsall, Demarcus Robinson, Russell Gage, and Robbie Chosen are assessed, with Amari Cooper floated as an outside option. Jake Moody’s shaky status adds another pressure point for Week 1 planning.

Amid the backdrop, Brock Purdy's leadership and Shanahan’s system anchor a Patriots-style defense rebuild under Salah, while young talents and depth players must grow quickly. Fantasy implications hinge on how SF divvies targets behind Brandon Aiyuk and McCaffrey, and whether the offense can sustain consistent production if Jennings’ situation remains unresolved.

Detroit’s 2025 ceiling hinges on a healthy offensive line led by Frank Ragnow, with Taylor Decker and Penei Sewell anchoring the tackles and Sam LaPorta providing a mismatch threat at tight end. If the unit stays together, Gibbs and Montgomery can unlock a top-tier ground game and the duo of weapons around Jared Goff can keep the passing attack humming.

Across the NFC, Purdy’s connection with Ricky Pearsall could sharpen San Francisco’s aerial plan, even as Debo Samuel shifts to Washington. Kansas City remains formidable with Mahomes at the helm and an improved line. Cleveland’s QB situation is a wild card, while FanDuel’s Futures Day nods to the Giants as a sneaky breakout pick in the NFC.

In Week 1 against Seattle, San Francisco’s injury wave compresses the attack. With seven receivers sidelined and multiple backs down, the plan leans toward heavy personnel with Christian McCaffrey and George Kittle anchored by a thin pass-catching corps. Luke Farrell and Ricky Pearsall push for roles as Jacob Cowing steps in, while Brian Robinson Jr.’s trade adds a veteran floor behind the star back. The result is a disciplined, route-agnostic game plan focused on matchups and depth, not splash plays, as SF tries to survive a banged-up start and lean into a favorable early schedule.